Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Recent studies have suggested that RET/PTC may be the cause of this specific nuclear change in PTC; however, the role of RET/PTC in tumor progression still needs to be defined.
|
12665647 |
2002 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
However, the prevalence of RET/PTC differs considerably among investigators, and its impact on cancer progression has been controversial.
|
19495791 |
2009 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The RET receptor tyrosine kinase mediates cell proliferation, survival and migration in embryogenesis and is implicated in the transformation and tumour progression in multiple cancers.
|
27872141 |
2017 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Up-regulation of GDNF and RET ligand-receptor interaction might participate in the glucose-induced cancer progression.
|
20960036 |
2011 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Here, we found a novel RET fusion gene, KIAA1217-RET, and examined the functional differences of RET51 and RET9 protein, fused with KIAA1217 in cancer progression and drug response.
|
27150058 |
2016 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Combining several agents would seem to be more promising, in particular agents that target RET with those that independently target RET signalling pathways or the more general mechanism of tumour progression.
|
25627652 |
2015 |
Tumor Progression
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
To explain this finding, we can hypothesize either that other oncogene(s) might be responsible for the majority of microMTC, thus identifying a tumor subset, or that the RET mutation might, or might not, occur later during tumor progression.
|
22404432 |
2012 |
Tumor Progression
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
This deletion causes RET loss of heterozygosity exclusively in the metastasis, thus suggesting a role for this second mutational event in tumor progression.
|
11232007 |
2001 |
Tumor Progression
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Although RET mutation is likely sufficient to cause C-cell hyperplasia, the precursor lesion to MTC, tumor progression is thought to be due to clonal expansion caused by the accumulation of somatic events.
|
12679485 |
2003 |
Tumor Progression
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
A wide range of genetic alterations have been described for the different subtypes of NETs, but the mechanisms underlying tumor development are essentially unknown except for MEN-2, in which an activating mutation of the RET proto-oncogene drives tumor progression and affords a direct genotype/phenotype correlation.
|
23391111 |
2013 |
Tumor Progression
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
These data indicate that RET rearrangements may not play any distinctive role in driving histotype development and cancer progression in these neoplasms.
|
12720532 |
2003 |